Advances & More News / Reported from Spain: 25(OH)Vitamin D Deficiency and Calcifediol Treatment in Pediatrics

Vitamin D is an essential nutrient for normalizing bone mineralization during childhood. Even though a proper diet and adequate sun exposure must provide enough Vitamin D still, there is a high prevalence of this of vitamin D deficiency rickets worldwide. Children with specific conditions that cause a reduction in Vitamin D production and absorption are at higher risk of nutritional rickets. On top of that, many rare genetic changes are linked to severe forms of vitamin-D-resistant or -dependent rickets. Health care providers use calcifediol (or 25(OH)D) serum levels to evaluate VDES status. Despite no clear consensus among the different scientific associations on calcifediol status, several clinical trials have shown the benefit of ensuring normal 25(OH)D serum levels and calcium intake for nutritional rickets in childhood prevention or treatment. Hence, infants must receive vitamin D treatment with at least 400 IU/day in the first year of life. On top of that, a proper diet must be followed to ensure a normal calcium intake, and a healthy lifestyle must be practiced during childhood to prevent Vitamin D deficiency. Furthermore, it is essential to provide adequate treatment with vitamin D and calcium among children with clinical signs of rickets. Besides, children with additional risk factors for 25(OH)D deficiency and nutritional rickets must be evaluated periodically and treated promptly to prevent further bone damage. By: Advances and More Medical Reporters Reference: Castano, L., Madariaga, L., Grau, G., & García-Castaño, A. (2022). 25(OH)Vitamin D Deficiency and Calcifediol Treatment in Pediatrics. Nutrients, 14(9), 1854.
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