Medical News / From ASH 2021 - Novel Lentiviral Vectors Achieve Efficient Correction of Sickling Phenotype

Investigators aimed to improve lentiviral vectors to boost therapeutic β-like globin levels without increasing the mutagenic vector load in hematopoietic stem/progenitor cells. Investigators from Europe created a lentiviral vector able to concomitantly silence the βS-globin and express β-Alanine synthase (βAS), achieving clinically relevant levels of therapeutic hemoglobin (Hb) and efficient correction of the sickling phenotype. Source: MDMag To view the third party content, kindly click on the link below or read more. You will then leave this site and enter a third party site.

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