Medical News / Directly from ACG: Vonoprazan Is Effective Against Heartburn in Symptomatic NERD

On-demand treatment with vonoprazan completely resolved heartburn in less than 3 hours with sustained relief for at least 24 hours in up to 70% of patients with symptomatic nonerosive reflux disease (NERD), according to findings from a phase 2 randomized trial presented at the American College of Gastroenterology (ACG) 2022 Annual Scientific Meeting in Charlotte, NC. In the study, vonoprazan, a potassium-competitive acid blocker (P-CAB), was administered at 3 doses and compared with a placebo as an on-demand treatment for heartburn episodes. In the study, complete and sustained relief was experienced by 56.0%, 60.6%, and 70.0% of patients treated with 10-mg, 20-mg, and 40-mg vonoprazan, respectively, as compared with 27.3% in the placebo arm. All 3 doses were statistically superior to placebo (P <.0001) and there were no rescue antacids required. Source: MDMag. To view the third party content, kindly click on the link below or read more. You will then ...

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